CCR Translations Enhancing Cancer Vaccine Efficacy via Modulation of the Tumor Microenvironment
نویسنده
چکیده
The development of therapeutic cancer vaccines is impacted by immunosuppressive elements in the tumor microenvironment. Most immunogenic cancer proteins are “self,” therefore, peripheral tolerance contributes substantially to tumor immune escape. Transforminggrowth factorβ (TGFβ) activelymodulatesboth inflammationand tolerance induction. Combining vaccination with agents that disarm TGFβ will enhance vaccine efficacy. (Clin Cancer Res 2009;15(21):6476–8)
منابع مشابه
Enhancing cancer vaccine efficacy via modulation of the tumor microenvironment.
The development of therapeutic cancer vaccines is impacted by immunosuppressive elements in the tumor microenvironment. Most immunogenic cancer proteins are "self," therefore, peripheral tolerance contributes substantially to tumor immune escape. Transforming growth factor beta (TGFbeta) actively modulates both inflammation and tolerance induction. Combining vaccination with agents that disarm ...
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تاریخ انتشار 2009